Preheat the oven to 350ºF. In a small bowl stir together the breadcrumbs, smoked paprika, garlic powder, and salt. In a separate small bowl, lightly whisk the egg.
Finely mince the onion. Roughly chop the cheddar cheese so that it is in pieces about the same size as a small bean.
Add the ground beef, seasoned breadcrumbs, whisked egg, minced onion, and chopped cheddar to a bowl. Use your hands to mix the ingredients together until incorporated.
Place the meat mixture in a casserole dish or on a rimmed baking sheet and shape into a rectangle, approximately 7″ long, 4″ wide, and 1.5″ thick.
To make the glaze, stir together the ketchup, brown sugar, mustard, and Worcestershire sauce. Spread the glaze over the unbaked meatloaf.
Bake the meatloaf in the preheated oven for 50-55 minutes, or until the internal temperature reaches 160ºF. Remove the meatloaf from the oven, let it sit for 5-10 minutes, then slice into eight pieces and serve.